Mouse Anti-PGRMC1 Recombinant Antibody (CBT4312) (V2LY-0625-LY476)

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Tested Data
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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBT4312
Application
IHC, ICC, FC
Immunogen
Purified recombinant fragment of human PGRMC1 (AA: 1-195) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Progesterone Receptor Membrane Component 1
Entrez Gene ID
UniProt ID
Function
Component of a progesterone-binding protein complex (PubMed:28396637).
Binds progesterone (PubMed:25675345).
Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036).
Biological Process
Associative learningIEA:Ensembl
Axon guidanceIEA:Ensembl
Heme biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
MemoryIEA:Ensembl
Modification of synaptic structureIEA:Ensembl
Negative regulation of synapse organizationIEA:Ensembl
Positive regulation of protein localization to plasma membraneIEA:Ensembl
Cellular Location
Microsome membrane
Smooth endoplasmic reticulum membrane
Mitochondrion outer membrane
Topology
Lumenal: 1-24
Helical: 25-43
Cytoplasmic: 44-195
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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