Mouse Anti-PGRMC1 Recombinant Antibody (C-4) (CBMAB-P1628-YC)

Name: Mouse Anti-PGRMC1 Recombinant Antibody (C-4)
SKU: CBMAB-P1628-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

C-4

Application

WB, IP, IF, IHC-P, ELISA

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Progesterone Receptor Membrane Component 1

Introduction

PGRMC1 is a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney.

Entrez Gene ID

Human	10857
Mouse	53328
Rat	291948

UniProt ID

Human	O00264
Mouse	O55022
Rat	P70580

Alternative Names

Progesterone Receptor Membrane Component 1; HPR6.6; DAP1; MPR; IZA; Membrane-Associated Progesterone Receptor Component 1; Progesterone Binding Protein; PGRMC;

Function

Component of a progesterone-binding protein complex (PubMed:28396637).
Binds progesterone (PubMed:25675345).
Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036).

Biological Process

Associative learningIEA:Ensembl
Axon guidanceIEA:Ensembl
Heme biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
MemoryIEA:Ensembl
Modification of synaptic structureIEA:Ensembl
Negative regulation of synapse organizationIEA:Ensembl
Positive regulation of protein localization to plasma membraneIEA:Ensembl

Cellular Location

Microsome membrane
Smooth endoplasmic reticulum membrane
Mitochondrion outer membrane

Topology

Lumenal: 1-24
Helical: 25-43
Cytoplasmic: 44-195

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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