PGRMC1

This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
Full Name
Progesterone Receptor Membrane Component 1
Function
Component of a progesterone-binding protein complex (PubMed:28396637).
Binds progesterone (PubMed:25675345).
Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036).
Biological Process
Associative learningIEA:Ensembl
Axon guidanceIEA:Ensembl
Heme biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
MemoryIEA:Ensembl
Modification of synaptic structureIEA:Ensembl
Negative regulation of synapse organizationIEA:Ensembl
Positive regulation of protein localization to plasma membraneIEA:Ensembl
Cellular Location
Microsome membrane
Smooth endoplasmic reticulum membrane
Mitochondrion outer membrane
Topology
Lumenal: 1-24
Helical: 25-43
Cytoplasmic: 44-195
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Anti-PGRMC1 antibodies

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Rabbit Anti-PGRMC1 Recombinant Antibody (D6M5M) (CBMAB-P1629-YC)

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Target: PGRMC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D6M5M
Application*: WB, IP, P, IF
Datasheet SDS

Mouse Anti-PGRMC1 Recombinant Antibody (C-4) (CBMAB-P1628-YC)

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Target: PGRMC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C-4
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-PGRMC1 Recombinant Antibody (1C10D11) (CBMAB-P1626-YC)

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Target: PGRMC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1C10D11
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-PGRMC1 Monoclonal Antibody (3F7) (CBMAB-1442-YC)

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Target: PGRMC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F7
Application*: E, WB
Datasheet SDS

Mouse Anti-PGRMC1 Recombinant Antibody (CBT4105) (V2LY-0625-LY477)

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Target: PGRMC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4105
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-PGRMC1 Recombinant Antibody (CBT4312) (V2LY-0625-LY476)

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Target: PGRMC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4312
Application*: IH, IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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