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Mouse Anti-PLSCR3 Recombinant Antibody (4B5) (CBMAB-P2181-YC)

Provided herein is a Mouse monoclonal antibody against Human Phospholipid Scramblase 3. The antibody can be used for immunoassay techniques, such as WB.
See all PLSCR3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
4B5
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to aa 1-296 of human PLSCR3
Specificity
Human, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-296

Target

Full Name
PLSCR3
Introduction
PLSCR3 (Phospholipid Scramblase 3) is a protein coding gene. Gene Ontology annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of the gene is PLSCR1.
Entrez Gene ID
Human57048
Rat360549
UniProt ID
HumanQ9NRY6
RatQ6QBQ4
Alternative Names
PL Scramblase 3; Ca(2+)-Dependent Phospholipid Scramblase 3
Function
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662).
Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:12649167).
Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:14573790, PubMed:17226776, PubMed:18358005).
Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:18491232).
Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:16939411).
Biological Process
Apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Cardiolipin biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to lipopolysaccharideIEA:Ensembl
Cholesterol homeostasisIEA:Ensembl
Glucose homeostasisIEA:Ensembl
Plasma membrane phospholipid scramblingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Mitochondrion membrane
Mitochondrion inner membrane
Nucleus
Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus.
Topology
Cytoplasmic: 1-265
Helical: 266-282
PTM
Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances phospholipid scramblase activity.
Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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