PLSCR3

PLSCR3 (Phospholipid Scramblase 3) is a protein coding gene. Gene Ontology annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of the gene is PLSCR1.

Full Name

PLSCR3

Function

Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662).
Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:12649167).
Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:14573790, PubMed:17226776, PubMed:18358005).
Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:18491232).
Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:16939411).

Biological Process

Apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Cardiolipin biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to lipopolysaccharideIEA:Ensembl
Cholesterol homeostasisIEA:Ensembl
Glucose homeostasisIEA:Ensembl
Plasma membrane phospholipid scramblingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Mitochondrion membrane
Mitochondrion inner membrane
Nucleus
Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus.

Topology

Cytoplasmic: 1-265
Helical: 266-282

PTM

Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances phospholipid scramblase activity.
Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus.