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Mouse Anti-PLSCR3 Recombinant Antibody (4F5) (CBMAB-A6820-LY)

The product is antibody recognizes PLSCR3. The antibody 4F5 immunoassay techniques such as: WB, ELISA.
See all PLSCR3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4F5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PLSCR3 (NP_065093.2, 74 a.a. ~ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PLSCR3
Entrez Gene ID
57048
UniProt ID
Q9NRY6
Function
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662).
Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:12649167).
Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:14573790, PubMed:17226776, PubMed:18358005).
Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:18491232).
Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:16939411).
Biological Process
Apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Cardiolipin biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to lipopolysaccharideIEA:Ensembl
Cholesterol homeostasisIEA:Ensembl
Glucose homeostasisIEA:Ensembl
Plasma membrane phospholipid scramblingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Mitochondrion membrane
Mitochondrion inner membrane
Nucleus
Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus.
Topology
Cytoplasmic: 1-265
Helical: 266-282
PTM
Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances phospholipid scramblase activity.
Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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