Rabbit Anti-PLXNA2 Recombinant Antibody (11C1060) (CBMAB-P2195-YC)

Name: Rabbit Anti-PLXNA2 Recombinant Antibody (11C1060)
SKU: CBMAB-P2195-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

11C1060

Application

IP, WB

Immunogen

Synthetic peptide corresponding to residues surrounding Gly185 of human Plexin A2.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

plexin A2

Introduction

PLXNA2 is a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion.

Entrez Gene ID

5362

UniProt ID

O75051

Alternative Names

OCT; PLXN2

Function

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Biological Process

Centrosome localizationIEA:Ensembl
Cerebellar granule cell precursor tangential migrationIEA:Ensembl
Limb bud formationIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neural tube developmentIEA:Ensembl
Pharyngeal system developmentIEA:Ensembl
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationISS:UniProtKB
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathwayISS:UniProtKB
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
SomitogenesisIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 35-1237
Helical: 1238-1258
Cytoplasmic: 1259-1894

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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