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Mouse Anti-PLXNA2 Recombinant Antibody (2G5) (CBMAB-P2196-YC)

Provided herein is a Mouse monoclonal antibody against Human Plexin A2. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PLXNA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G5
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PLXNA2 (AAH32125, 1-164 aa) full length recombinant protein with GST tag. Immunogen sequence: MHSQVFSAFP YSLPLRFWVN VIKNPQFVFD IHKGSITDAC LSVVAQTFMD SCSTSEHRLD KDSPSNKLLY AKDIPSYKSW VERYYADIAK LPAISDQDMN AYLAEQSRLH AVEFNMLSAL NEIYSYVSKY SEELIGALEQ DEQARRQRLA YKVEQLINAM SIES
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-164

Target

Full Name
plexin A2
Introduction
PLXNA2 is a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion.
Entrez Gene ID
5362
UniProt ID
O75051
Alternative Names
OCT; PLXN2
Function
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Biological Process
Centrosome localizationIEA:Ensembl
Cerebellar granule cell precursor tangential migrationIEA:Ensembl
Limb bud formationIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neural tube developmentIEA:Ensembl
Pharyngeal system developmentIEA:Ensembl
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationISS:UniProtKB
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathwayISS:UniProtKB
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
SomitogenesisIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 35-1237
Helical: 1238-1258
Cytoplasmic: 1259-1894
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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