PLXNA2

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq]
Full Name
plexin A2
Function
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Biological Process
Centrosome localizationIEA:Ensembl
Cerebellar granule cell precursor tangential migrationIEA:Ensembl
Limb bud formationIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neural tube developmentIEA:Ensembl
Pharyngeal system developmentIEA:Ensembl
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationISS:UniProtKB
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathwayISS:UniProtKB
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
SomitogenesisIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 35-1237
Helical: 1238-1258
Cytoplasmic: 1259-1894
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Anti-PLXNA2 antibodies

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Rat Anti-PLXNA2 Recombinant Antibody (RM0503-6L43) (CBMAB-1669-CN)

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Target: PLXNA2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0503-6L43
Application*: WB
Datasheet SDS

Rabbit Anti-PLXNA2 Recombinant Antibody (D44D4) (CBMAB-CP2027-LY)

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Target: PLXNA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D44D4
Application*: WB
Datasheet SDS

Rabbit Anti-PLXNA2 Recombinant Antibody (D42B5) (CBMAB-CP2026-LY)

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Target: PLXNA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D42B5
Application*: WB, IP
Datasheet SDS

Mouse Anti-PLXNA2 Recombinant Antibody (CBYC-P462) (CBMAB-P2198-YC)

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Target: PLXNA2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYC-P462
Application*: WB
Datasheet SDS

Rat Anti-PLXNA2 Recombinant Antibody (CBYC-P461) (CBMAB-P2197-YC)

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Target: PLXNA2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYC-P461
Application*: IC, IF, WB
Datasheet SDS

Mouse Anti-PLXNA2 Recombinant Antibody (2G5) (CBMAB-P2196-YC)

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Target: PLXNA2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2G5
Application*: E, WB
Datasheet SDS

Rabbit Anti-PLXNA2 Recombinant Antibody (11C1060) (CBMAB-P2195-YC)

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Target: PLXNA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 11C1060
Application*: IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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