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Mouse Anti-POSTN Recombinant Antibody (2B2) (CBMAB-P2416-YC)

Provided herein is a Mouse monoclonal antibody against Human Periostin. The antibody can be used for immunoassay techniques, such as IHC-P.
See all POSTN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B2
Antibody Isotype
IgG2a
Application
IHC-P

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 538-781 of human POSTN (NP_001129407) produced in E. coli.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Periostin
Introduction
POSTN is a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects.
Entrez Gene ID
10631
UniProt ID
Q15063
Alternative Names
OSF-2; OSF2; PDLPOSTN; PN
Function
Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007).
Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).
Biological Process
Cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to vitamin KManual Assertion Based On ExperimentIDA:UniProtKB
Extracellular matrix organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of Notch signaling pathwayIEA:Ensembl
Tissue developmentIEA:Ensembl
Cellular Location
Golgi apparatus
Secreted
Secreted, extracellular space, extracellular matrix
Colocalizes with BMP1 in the Golgi.
PTM
Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding (PubMed:18450759).
According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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