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Mouse Anti-PPM1A Recombinant Antibody (CBFYM-3071) (CBMAB-M3267-FY)

This product is mouse antibody that recognizes PPM1A. The antibody CBFYM-3071 can be used for immunoassay techniques such as: IF.
See all PPM1A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3071
Application
IF

Basic Information

Immunogen
Recombinant Human PPM1A/PP2C-alpha protein
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Introduction
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways.
Entrez Gene ID
5494
UniProt ID
P35813
Alternative Names
PP2CA; PP2Calpha; PP2C-ALPHA
Function
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Biological Process
Cellular response to transforming growth factor beta stimulusIEA:Ensembl
DephosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
N-terminal protein myristoylationISS:UniProtKB
Negative regulation of BMP signaling pathwayIEA:Ensembl
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of SMAD protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IITAS:Reactome
Negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Positive regulation of protein export from nucleusIEA:Ensembl
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:BHF-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein export from nucleusIEA:Ensembl
Regulation of cell cycleTAS:Reactome
Cellular Location
Nucleus
Cytoplasm, cytosol
Membrane
Weakly associates at the membrane and N-myristoylation mediates the membrane localization.
PTM
N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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