Human Recombinant PPM1A, Active protein, GST Tag-1 (V2LY-0526-LY6265)

Name: Human Recombinant PPM1A, Active protein, GST Tag-1
SKU: V2LY-0526-LY6265
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant PPM1A, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 70 kDa.

Molecule Mass

70 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, DTT, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform

Function

Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Biological Process

Cellular response to transforming growth factor beta stimulusIEA:Ensembl
DephosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
N-terminal protein myristoylationISS:UniProtKB
Negative regulation of BMP signaling pathwayIEA:Ensembl
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of SMAD protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IITAS:Reactome
Negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Positive regulation of protein export from nucleusIEA:Ensembl
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:BHF-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein export from nucleusIEA:Ensembl
Regulation of cell cycleTAS:Reactome

Cellular Location

Nucleus
Cytoplasm, cytosol
Membrane
Weakly associates at the membrane and N-myristoylation mediates the membrane localization.

PTM

N-myristoylation is essential for the recognition of its substrates for dephosphorylation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant PPM1A, Active protein, GST Tag (CAT#: V2LY-0526-LY6264)

Human Recombinant PPM1A protein, His Tag (CAT#: V2LY-0526-LY6266)

Mouse Recombinant PPM1A protein, His Tag (CAT#: V2LY-0526-LY8796)

Related Products

Human Recombinant PPM1A protein, His Tag (CAT#: V2LY-0526-LY6266)

Human Recombinant PPM1A, Active protein, GST Tag (CAT#: V2LY-0526-LY6264)

Mouse Anti-PPM1A Recombinant Antibody (7F12) (CAT#: CBMAB-P2552-YC)

Mouse Anti-PPM1A Recombinant Antibody (4E11) (CAT#: CBMAB-P2551-YC)

Mouse Anti-PPM1A Recombinant Antibody (CBFYM-3071) (CAT#: CBMAB-M3267-FY)

Mouse Anti-PPM1A Recombinant Antibody (13B635) (CAT#: CBMAB-P2550-YC)

Mouse Recombinant PPM1A protein, His Tag (CAT#: V2LY-0526-LY8796)

Mouse Anti-PPM1A Recombinant Antibody (p6c7) (CAT#: CBMAB-P2553-YC)

Mouse Anti-PPM1A Recombinant Antibody (11C45) (CAT#: CBMAB-P2549-YC)

Mouse Anti-PPM1A Recombinant Antibody (CBT2944) (CAT#: V2LY-0625-LY2752)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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