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Mouse Anti-PPM1A Recombinant Antibody (CBT2944) (V2LY-0625-LY2752)


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Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
CBT2944
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Entrez Gene ID
5494
UniProt ID
P20265
Function
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Biological Process
Cellular response to transforming growth factor beta stimulusIEA:Ensembl
DephosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
N-terminal protein myristoylationISS:UniProtKB
Negative regulation of BMP signaling pathwayIEA:Ensembl
Negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of SMAD protein complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IITAS:Reactome
Negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Positive regulation of protein export from nucleusIEA:Ensembl
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:BHF-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein export from nucleusIEA:Ensembl
Regulation of cell cycleTAS:Reactome
Cellular Location
Nucleus
Cytoplasm, cytosol
Membrane
Weakly associates at the membrane and N-myristoylation mediates the membrane localization.
PTM
N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
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For research use only. Not intended for any clinical use.

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