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Recombinant Mouse Anti-PPP1R13L Recombinant Antibody (49.3) (CBMAB-XB0954-YC)

Provided herein is a Mouse Recombinant Antibody against Protein Phosphatase 1 Regulatory Subunit 13 Like. The antibody can be used for immunoassay techniques, such as FC, IF, IP.
See all PPP1R13L antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
49.3
Application
FC, IF, IP

Basic Information

Immunogen
C-terminal His-tagged fusion protein containing amino acids 459-639 of iASPP
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PPP1R13L
Introduction
PPP1R13L (Protein Phosphatase 1 Regulatory Subunit 13 Like) is a protein coding gene. Diseases associated with PPP1R13L include Noonan Syndrome With Multiple Lentiginesand Spinal Chordoma. Among its related pathways are Gene Expression and p53 pathway. Gene Ontology annotations related to this gene include identical protein binding andtranscription corepressor activity. An important paralog of this gene is TP53BP2.
Entrez Gene ID
10848
UniProt ID
Q8WUF5
Alternative Names
IASPP; Inhibitor Of ASPP Protein
Function
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540).
Biological Process
Apoptotic processIEA:UniProtKB-KW
Cardiac muscle contractionIEA:Ensembl
Cardiac right ventricle morphogenesisIEA:Ensembl
Embryonic camera-type eye developmentIEA:Ensembl
Hair cycleIEA:Ensembl
Multicellular organism growthIEA:Ensembl
Multicellular organismal homeostasisIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Post-embryonic developmentIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Ventricular cardiac muscle tissue developmentIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Predominantly cytoplasmic but also nuclear.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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