PPP1R13L

PPP1R13L (Protein Phosphatase 1 Regulatory Subunit 13 Like) is a protein coding gene. Diseases associated with PPP1R13L include Noonan Syndrome With Multiple Lentiginesand Spinal Chordoma. Among its related pathways are Gene Expression and p53 pathway. Gene Ontology annotations related to this gene include identical protein binding andtranscription corepressor activity. An important paralog of this gene is TP53BP2.

Full Name

PPP1R13L

Function

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540).

Biological Process

Apoptotic processIEA:UniProtKB-KW
Cardiac muscle contractionIEA:Ensembl
Cardiac right ventricle morphogenesisIEA:Ensembl
Embryonic camera-type eye developmentIEA:Ensembl
Hair cycleIEA:Ensembl
Multicellular organism growthIEA:Ensembl
Multicellular organismal homeostasisIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Post-embryonic developmentIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Ventricular cardiac muscle tissue developmentIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus
Predominantly cytoplasmic but also nuclear.