Mouse Anti-PTBP2 Recombinant Antibody (2D10-B2) (CBMAB-A7157-LY)

Name: Mouse Anti-PTBP2 Recombinant Antibody (2D10-B2)
SKU: CBMAB-A7157-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2D10-B2

Application

WB, ELISA

Immunogen

PTBP2 (AAH16582.1, 35 a.a. ~ 175 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

polypyrimidine tract binding protein 2

Introduction

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein but it is expressed primarily in the brain. [provided by RefSeq]

Entrez Gene ID

58155

UniProt ID

Q9UKA9

Alternative Names

FLJ34897; PTB; PTBLP; brPTB; nPTB; nPTB5; nPTB6; nPTB7; nPTB8

Function

RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.
Isoform 5
Reduced affinity for RNA.

Biological Process

Cerebellum developmentIEA:Ensembl
mRNA splice site selectionIEA:Ensembl
Negative regulation of RNA splicingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of neural precursor cell proliferationIEA:Ensembl
Regulation of RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord developmentIEA:Ensembl

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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