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Rabbit Anti-PTBP2 Recombinant Antibody (BA0381) (CBMAB-0742CQ)

This product is a rabbit antibody that recognizes PTBP2. The antibody BA0381 can be used for immunoassay techniques such as: IF, IHC-P, WB.
See all PTBP2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0381
Antibody Isotype
IgG
Application
IF, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide from residues in Human PTBP2
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
polypyrimidine tract binding protein 2
Introduction
The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.
Entrez Gene ID
Human58155
Mouse56195
Rat310820
UniProt ID
HumanQ9UKA9
MouseQ91Z31
RatQ66H20
Alternative Names
nPTB; PTBLP; brPTB
Function
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.
Isoform 5
Reduced affinity for RNA.
Biological Process
Cerebellum developmentIEA:Ensembl
mRNA splice site selectionIEA:Ensembl
Negative regulation of RNA splicingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of neural precursor cell proliferationIEA:Ensembl
Regulation of RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord developmentIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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