PTBP2

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein but it is expressed primarily in the brain. [provided by RefSeq]

Full Name

polypyrimidine tract binding protein 2

Function

RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.
Isoform 5
Reduced affinity for RNA.

Biological Process

Cerebellum developmentIEA:Ensembl
mRNA splice site selectionIEA:Ensembl
Negative regulation of RNA splicingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of neural precursor cell proliferationIEA:Ensembl
Regulation of RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord developmentIEA:Ensembl

Cellular Location

Nucleus

Anti-PTBP2 antibodies

Rabbit Anti-PTBP2 Recombinant Antibody (BA0381) (CBMAB-0742CQ)

Datasheet

SDS

Target: PTBP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: BA0381

Application*: IF, P, WB

Mouse Anti-PTBP2 Recombinant Antibody (BA0418) (CBMAB-0741CQ)

Datasheet

SDS

Target: PTBP2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: BA0418

Application*: WB, F

Mouse Anti-PTBP2 Recombinant Antibody (2D10-B2) (CBMAB-A7157-LY)

Datasheet

SDS

Target: PTBP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2D10-B2

Application*: WB, E

Mouse Anti-PTBP2 Recombinant Antibody (CBYC-P738) (CBMAB-P3289-YC)

Datasheet

SDS

Target: PTBP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P738

Application*: E, WB

Mouse Anti-PTBP2 Recombinant Antibody (2B11) (CBMAB-P3286-YC)

Datasheet

SDS

Target: PTBP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2B11

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)