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PTBP2

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein but it is expressed primarily in the brain. [provided by RefSeq]

Full Name

polypyrimidine tract binding protein 2

Function

RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.
Isoform 5
Reduced affinity for RNA.

Biological Process

Cerebellum developmentIEA:Ensembl
mRNA splice site selectionIEA:Ensembl
Negative regulation of RNA splicingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of neural precursor cell proliferationIEA:Ensembl
Regulation of RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord developmentIEA:Ensembl

Cellular Location

Nucleus

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Anti-PTBP2 antibodies

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Mouse Anti-PTBP2 Recombinant Antibody (2D10-B2) (CBMAB-A7157-LY)

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Target: PTBP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2D10-B2

Application*: WB, E

Mouse Anti-PTBP2 Recombinant Antibody (CBYC-P738) (CBMAB-P3289-YC)

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Target: PTBP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P738

Application*: E, WB

Mouse Anti-PTBP2 Recombinant Antibody (2B11) (CBMAB-P3286-YC)

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Target: PTBP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2B11

Application*: WB

Rabbit Anti-PTBP2 Recombinant Antibody (BA0381) (CBMAB-0742CQ)

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Target: PTBP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: BA0381

Application*: IF, P, WB

Mouse Anti-PTBP2 Recombinant Antibody (BA0418) (CBMAB-0741CQ)

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Target: PTBP2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: BA0418

Application*: WB, F

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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