PTBP2

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein but it is expressed primarily in the brain. [provided by RefSeq]
Full Name
polypyrimidine tract binding protein 2
Function
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.
Isoform 5
Reduced affinity for RNA.
Biological Process
Cerebellum developmentIEA:Ensembl
mRNA splice site selectionIEA:Ensembl
Negative regulation of RNA splicingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of neural precursor cell proliferationIEA:Ensembl
Regulation of RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord developmentIEA:Ensembl
Cellular Location
Nucleus
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Anti-PTBP2 antibodies

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Mouse Anti-PTBP2 Recombinant Antibody (2D10-B2) (CBMAB-A7157-LY)

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Target: PTBP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D10-B2
Application*: WB, E
Datasheet SDS

Mouse Anti-PTBP2 Recombinant Antibody (CBYC-P738) (CBMAB-P3289-YC)

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Target: PTBP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P738
Application*: E, WB
Datasheet SDS

Mouse Anti-PTBP2 Recombinant Antibody (2B11) (CBMAB-P3286-YC)

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Target: PTBP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B11
Application*: WB
Datasheet SDS

Rabbit Anti-PTBP2 Recombinant Antibody (BA0381) (CBMAB-0742CQ)

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Target: PTBP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0381
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-PTBP2 Recombinant Antibody (BA0418) (CBMAB-0741CQ)

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Target: PTBP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BA0418
Application*: WB, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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