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Mouse Anti-PTBP2 Recombinant Antibody (CBYC-P738) (CBMAB-P3289-YC)

Provided herein is a Mouse monoclonal antibody against Human Polypyrimidine tract binding protein 2. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PTBP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P738
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2, 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-533

Target

Full Name
polypyrimidine tract binding protein 2
Introduction
PTBP2 binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain.
Entrez Gene ID
58155
UniProt ID
Q9UKA9
Alternative Names
PTBLP; brPTB; nPTB
Function
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.
Isoform 5
Reduced affinity for RNA.
Biological Process
Cerebellum developmentIEA:Ensembl
mRNA splice site selectionIEA:Ensembl
Negative regulation of RNA splicingManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of neural precursor cell proliferationIEA:Ensembl
Regulation of RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord developmentIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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