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Mouse Anti-PTPRB Recombinant Antibody (CBFYH-3641) (CBMAB-H4201-FY)

This product is mouse antibody that recognizes PTPRB. The antibody CBFYH-3641 can be used for immunoassay techniques such as: IF, IHC.
See all PTPRB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3641
Antibody Isotype
IgG
Application
IF, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase, receptor type B
Introduction
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
Entrez Gene ID
5787
UniProt ID
P23467
Alternative Names
PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA
Function
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
Biological Process
AngiogenesisManual Assertion Based On ExperimentIBA:GO_Central
DephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Glial cell migrationIEA:Ensembl
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Phosphate-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Extracellular: 23-1621
Helical: 1622-1642
Cytoplasmic: 1643-1997
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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