Mouse Anti-PTPRB Recombinant Antibody (CBFYH-3642) (CBMAB-H4202-FY)

Name: Mouse Anti-PTPRB Recombinant Antibody (CBFYH-3642)
SKU: CBMAB-H4202-FY
Rating: 5 (1 reviews)

See all PTPRB antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-3642

Application

ICC, IF, IP, WB

Specificity

Rat

Antibody Isotype

IgM

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Protein tyrosine phosphatase, receptor type B

Introduction

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

Entrez Gene ID

314843

UniProt ID

A0A0G2K2W0

Alternative Names

PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA

Function

Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Biological Process

AngiogenesisManual Assertion Based On ExperimentIBA:GO_Central
DephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Glial cell migrationIEA:Ensembl
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Phosphate-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Membrane

Topology

Extracellular: 23-1621
Helical: 1622-1642
Cytoplasmic: 1643-1997

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-PTPRB Recombinant Antibody (CBFYH-3642)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PTPRB Recombinant Antibody (CBFYH-3641) (CAT#: CBMAB-H4201-FY)

Mouse Anti-PTPRB Recombinant Antibody (2-A2) (CAT#: CBMAB-P3453-YC)

Human PTPRB ELISA Kit (CAT#: V2LY-0626-LY3074)

Human Recombinant PTPRB, Active protein, GST Tag (CAT#: V2LY-0526-LY6416)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry