Human PTPRB ELISA Kit (V2LY-0626-LY3074)

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Basic Information

Sensitivity
0.0092 ng/mL
Detection Range
0.02-7 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
224.3 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Protein tyrosine phosphatase, receptor type B
Function
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
Biological Process
AngiogenesisManual Assertion Based On ExperimentIBA:GO_Central
DephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Glial cell migrationIEA:Ensembl
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Phosphate-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Extracellular: 23-1621
Helical: 1622-1642
Cytoplasmic: 1643-1997
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant PTPRB, Active protein, GST Tag (CAT#: V2LY-0526-LY6416)

Related Products

Mouse Anti-PTPRB Recombinant Antibody (2-A2) (CAT#: CBMAB-P3453-YC)

Mouse Anti-PTPRB Recombinant Antibody (CBFYH-3642) (CAT#: CBMAB-H4202-FY)

Human Recombinant PTPRB, Active protein, GST Tag (CAT#: V2LY-0526-LY6416)

Mouse Anti-PTPRB Recombinant Antibody (CBFYH-3641) (CAT#: CBMAB-H4201-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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