Human Recombinant PTPRB, Active protein, GST Tag (V2LY-0526-LY6416)

Name: Human Recombinant PTPRB, Active protein, GST Tag
SKU: V2LY-0526-LY6416
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant PTPRB, Active protein, GST Tag consist of Amino Acid: 1552-end and predicts a molecular mass of 116 kDa.

Molecule Mass

116 kDa

Sequence

Amino Acid: 1552-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Protein tyrosine phosphatase, receptor type B

Function

Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Biological Process

AngiogenesisManual Assertion Based On ExperimentIBA:GO_Central
DephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Glial cell migrationIEA:Ensembl
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Phosphate-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Membrane

Topology

Extracellular: 23-1621
Helical: 1622-1642
Cytoplasmic: 1643-1997

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human PTPRB ELISA Kit (CAT#: V2LY-0626-LY3074)

Related Products

Mouse Anti-PTPRB Recombinant Antibody (CBFYH-3641) (CAT#: CBMAB-H4201-FY)

Mouse Anti-PTPRB Recombinant Antibody (CBFYH-3642) (CAT#: CBMAB-H4202-FY)

Human PTPRB ELISA Kit (CAT#: V2LY-0626-LY3074)

Mouse Anti-PTPRB Recombinant Antibody (2-A2) (CAT#: CBMAB-P3453-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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