Mouse Anti-RHEB Recombinant Antibody (CBCNR-464) (CBMAB-R2511-CN)

Name: Mouse Anti-RHEB Recombinant Antibody (CBCNR-464)
SKU: CBMAB-R2511-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBCNR-464

Application

WB, ELISA

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

Ras Homolog, MTORC1 Binding

Introduction

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	6009
Mouse	19744
Rat	26954

UniProt ID

Human	Q15382
Mouse	Q921J2
Rat	Q62639

Alternative Names

Ras Homolog, MTORC1 Binding; Ras Homolog Enriched In Brain 2; Ras Homolog Enriched In Brain; RHEB2; GTP-Binding Protein Rheb;

Function

Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.

Biological Process

Biological Process negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Biological Process oligodendrocyte differentiationIEA:Ensembl
Biological Process positive regulation of oligodendrocyte differentiationIEA:Ensembl
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell cycleTAS:Reactome
Biological Process regulation of macroautophagyTAS:Reactome
Biological Process regulation of type B pancreatic cell developmentManual Assertion Based On ExperimentIMP:CACAO
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process small GTPase mediated signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Endomembrane system
Golgi apparatus membrane
Cytoplasm, cytosol
Endoplasmic reticulum membrane

PTM

Farnesylation is important for efficiently activating mTORC1-mediated signaling.
Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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