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Mouse Anti-RHEB Recombinant Antibody (CBCNR-464) (CBMAB-R2511-CN)

This product is a Mouse antibody that recognizes RHEB. The antibody CBCNR-464 can be used for immunoassay techniques such as: WB, ELISA.
See all RHEB antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBCNR-464
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
Ras Homolog, MTORC1 Binding
Introduction
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human6009
Mouse19744
Rat26954
UniProt ID
HumanQ15382
MouseQ921J2
RatQ62639
Alternative Names
Ras Homolog, MTORC1 Binding; Ras Homolog Enriched In Brain 2; Ras Homolog Enriched In Brain; RHEB2; GTP-Binding Protein Rheb;
Function
Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Biological Process
Biological Process negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Biological Process oligodendrocyte differentiationIEA:Ensembl
Biological Process positive regulation of oligodendrocyte differentiationIEA:Ensembl
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell cycleTAS:Reactome
Biological Process regulation of macroautophagyTAS:Reactome
Biological Process regulation of type B pancreatic cell developmentManual Assertion Based On ExperimentIMP:CACAO
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process small GTPase mediated signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endomembrane system
Golgi apparatus membrane
Cytoplasm, cytosol
Endoplasmic reticulum membrane
PTM
Farnesylation is important for efficiently activating mTORC1-mediated signaling.
Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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