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Mouse Anti-SCN2B Recombinant Antibody (CBXS-2936) (CBMAB-S5685-CQ)

This product is a mouse antibody that recognizes SCN2B. The antibody CBXS-2936 can be used for immunoassay techniques such as: ELISA.
See all SCN2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2936
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
Full length recombinant corresponding to aa1-216 from human SCN2B (AAH36793) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sodium Voltage-Gated Channel Beta Subunit 2
Introduction
The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome.
Entrez Gene ID
6327
UniProt ID
O60939
Alternative Names
Sodium Voltage-Gated Channel Beta Subunit 2; Sodium Channel, Voltage-Gated, Type II, Beta Polypeptide; Sodium Channel, Voltage Gated, Type II Beta Subunit; Sodium Channel, Voltage-Gated, Type II, Beta Subunit; Neuronal Voltage-Gated Sodium Channel Beta 2 Subunit; Sodium Channel, Voltage-Gated, Type II, Beta; Sodium Channel Subunit Beta-2; ATFB14;
Function
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
Biological Process
Biological Process cardiac muscle cell action potential involved in contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cardiac muscle contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process gene expressionIEA:Ensembl
Biological Process membrane depolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process nervous system developmentIEA:Ensembl
Biological Process regulation of atrial cardiac muscle cell membrane depolarizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process response to heatIEA:Ensembl
Biological Process response to pyrethroidIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Membrane
Involvement in disease
Atrial fibrillation, familial, 14 (ATFB14):
A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
Topology
Extracellular: 30-159
Helical: 160-180
Cytoplasmic: 181-215
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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