Rabbit Anti-SCN2B Recombinant Antibody (CBXS-5423) (CBMAB-S2634-CQ)

Name: Rabbit Anti-SCN2B Recombinant Antibody (CBXS-5423)
SKU: CBMAB-S2634-CQ
Rating: 5 (1 reviews)

See all SCN2B antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXS-5423

Application

WB, IP

Specificity

Mouse, Rat

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Sodium Voltage-Gated Channel Beta Subunit 2

Introduction

The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome.

Entrez Gene ID

Mouse	72821
Rat	25349

UniProt ID

Mouse	Q56A07
Rat	P54900

Alternative Names

2810451E09Rik; AI840361; Gm183

Function

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).

Biological Process

Biological Process cardiac muscle cell action potential involved in contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cardiac muscle contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process gene expressionIEA:Ensembl
Biological Process membrane depolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process nervous system developmentIEA:Ensembl
Biological Process regulation of atrial cardiac muscle cell membrane depolarizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process response to heatIEA:Ensembl
Biological Process response to pyrethroidIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Membrane

Involvement in disease

Atrial fibrillation, familial, 14 (ATFB14):
A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Topology

Extracellular: 30-159
Helical: 160-180
Cytoplasmic: 181-215

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-SCN2B Recombinant Antibody (CBXS-5423)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-SCN2B Recombinant Antibody (CBXS-5353) (CAT#: CBMAB-S2566-CQ)

Mouse Anti-SCN2B Recombinant Antibody (2G11-C12) (CAT#: CBMAB-A7929-LY)

Rabbit Anti-SCN2B Recombinant Antibody (D6L5Y) (CAT#: CBMAB-CP2369-LY)

Mouse Anti-SCN2B Recombinant Antibody (CBXS-2936) (CAT#: CBMAB-S5685-CQ)

Mouse Anti-SCN2B Recombinant Antibody (S395-68) (CAT#: CBMAB-N0596-WJ)

Rabbit Anti-SCN2B Recombinant Antibody (D1S8E) (CAT#: CBMAB-CP2368-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry