Human Recombinant SCN2B protein, hFc Tag (V2LY-0526-LY6684)

Name: Human Recombinant SCN2B protein, hFc Tag
SKU: V2LY-0526-LY6684
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant SCN2B protein, hFc Tag consist of Amino Acid: 1-159 and predicts a molecular mass of 42.2 kDa.

Molecule Mass

42.2 kDa

Sequence

Amino Acid: 1-159

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Sodium Voltage-Gated Channel Beta Subunit 2

Function

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).

Biological Process

Biological Process cardiac muscle cell action potential involved in contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cardiac muscle contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process gene expressionIEA:Ensembl
Biological Process membrane depolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process nervous system developmentIEA:Ensembl
Biological Process regulation of atrial cardiac muscle cell membrane depolarizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process response to heatIEA:Ensembl
Biological Process response to pyrethroidIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Membrane

Involvement in disease

Atrial fibrillation, familial, 14 (ATFB14):
A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Topology

Extracellular: 30-159
Helical: 160-180
Cytoplasmic: 181-215

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant SCN2B protein, His Tag (CAT#: V2LY-0526-LY6685)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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