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SCN2B

The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome.

Full Name

Sodium Voltage-Gated Channel Beta Subunit 2

Function

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).

Biological Process

Biological Process cardiac muscle cell action potential involved in contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cardiac muscle contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process gene expressionIEA:Ensembl
Biological Process membrane depolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process nervous system developmentIEA:Ensembl
Biological Process regulation of atrial cardiac muscle cell membrane depolarizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process response to heatIEA:Ensembl
Biological Process response to pyrethroidIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Membrane

Involvement in disease

Atrial fibrillation, familial, 14 (ATFB14):
A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Topology

Extracellular: 30-159
Helical: 160-180
Cytoplasmic: 181-215

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Anti-SCN2B antibodies

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Rabbit Anti-SCN2B Recombinant Antibody (CBXS-5423) (CBMAB-S2634-CQ)

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Target: SCN2B

Host: Rabbit

Specificity: Mouse, Rat

Clone: CBXS-5423

Application*: WB, IP

Mouse Anti-SCN2B Recombinant Antibody (2G11-C12) (CBMAB-A7929-LY)

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Target: SCN2B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2G11-C12

Application*: SE, E

Rat Scn2b ELISA Kit (V2LY-0626-LY2661)

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Target: Scn2b

Sensitivity: 0.056 ng/mL

Detection Range: 0.1-40 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Rat

Assay Type: Sandwich

Reactivity: Rat

Human Recombinant SCN2B protein, His Tag (V2LY-0526-LY6685)

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Target: SCN2B

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-159

Tag: His Tag

Human Recombinant SCN2B protein, hFc Tag (V2LY-0526-LY6684)

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Target: SCN2B

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-159

Tag: hFc Tag

Rabbit Anti-SCN2B Recombinant Antibody (D6L5Y) (CBMAB-CP2369-LY)

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Target: SCN2B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat

Clone: D6L5Y

Application*: WB, IP

Rabbit Anti-SCN2B Recombinant Antibody (D1S8E) (CBMAB-CP2368-LY)

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Target: SCN2B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D1S8E

Application*: WB, IP

Mouse Anti-SCN2B Recombinant Antibody (CBXS-2936) (CBMAB-S5685-CQ)

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Target: SCN2B

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-2936

Application*: E

Rabbit Anti-SCN2B Recombinant Antibody (CBXS-5353) (CBMAB-S2566-CQ)

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Target: SCN2B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXS-5353

Application*: WB, IP

Mouse Anti-SCN2B Recombinant Antibody (S395-68) (CBMAB-N0596-WJ)

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Target: SCN2B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Rat

Clone: S395-68

Application*: WB, IC

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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