Mouse Anti-SERPINI1 Recombinant Antibody (CBXS-0270) (CBMAB-S3246-CQ)

Name: Mouse Anti-SERPINI1 Recombinant Antibody (CBXS-0270)
SKU: CBMAB-S3246-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-0270

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Immunogen

Neuroserpin

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

serpin peptidase inhibitor, clade I (neuroserpin), member 1

Introduction

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Entrez Gene ID

5274

UniProt ID

Q99574

Alternative Names

Serpin Family I Member 1; Serine (Or Cysteine) Proteinase Inhibitor, Clade I (Neuroserpin), Member 1; Serpin Peptidase Inhibitor, Clade I (Neuroserpin), Member 1; Peptidase Inhibitor 12; Serpin I1; PI-12; PI12; Serpin Peptidase Inhibitor Clade I Member 1; Neuroserpin;

Function

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376).
May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).

Biological Process

Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peripheral nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of neuron projection developmentISS:ARUK-UCL
Biological Process regulation of cell adhesionIEA:Ensembl

Cellular Location

Secreted
Cytoplasmic vesicle, secretory vesicle lumen

Involvement in disease

Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB):
A neurodegenerative disease clinically characterized by dementia. Additional features include intellectual decline, psychic seizures, progressive myoclonic epilepsy, and cerebral atrophy. Histologically, it is characterized by the presence of eosinophilic inclusion bodies (called Collins bodies) throughout the deeper layers of the cerebral cortex, leading to neuronal death.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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