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Mouse Anti-SERPINI1 Recombinant Antibody (CBXS-3956) (CBMAB-S1219-CQ)

This product is a mouse antibody that recognizes SERPINI1. The antibody CBXS-3956 can be used for immunoassay techniques such as: WB, IHC-P.
See all SERPINI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3956
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Immunogen
Recombinant protein corresponding to aa 17-411 of human SERPINI1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
serpin peptidase inhibitor, clade I (neuroserpin), member 1
Introduction
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Entrez Gene ID
5274
UniProt ID
Q99574
Alternative Names
Serpin Family I Member 1; Serine (Or Cysteine) Proteinase Inhibitor, Clade I (Neuroserpin), Member 1; Serpin Peptidase Inhibitor, Clade I (Neuroserpin), Member 1; Peptidase Inhibitor 12; Serpin I1; PI-12; PI12; Serpin Peptidase Inhibitor Clade I Member 1; Neuroserpin;
Function
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376).
May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
Biological Process
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peripheral nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of neuron projection developmentISS:ARUK-UCL
Biological Process regulation of cell adhesionIEA:Ensembl
Cellular Location
Secreted
Cytoplasmic vesicle, secretory vesicle lumen
Involvement in disease
Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB):
A neurodegenerative disease clinically characterized by dementia. Additional features include intellectual decline, psychic seizures, progressive myoclonic epilepsy, and cerebral atrophy. Histologically, it is characterized by the presence of eosinophilic inclusion bodies (called Collins bodies) throughout the deeper layers of the cerebral cortex, leading to neuronal death.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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