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Rabbit Anti-SERPINI1 Recombinant Antibody (CBXS-5942) (CBMAB-S0791-CQ)

This product is a rabbit antibody that recognizes SERPINI1. The antibody CBXS-5942 can be used for immunoassay techniques such as: ELISA.
See all SERPINI1 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBXS-5942
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Mouse SerpinI1 protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
serpin peptidase inhibitor, clade I (neuroserpin), member 1
Introduction
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Entrez Gene ID
20713
UniProt ID
O35684
Alternative Names
AI837402; Ns; PI-12; PI12; Spi17
Function
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376).
May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
Biological Process
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peripheral nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of neuron projection developmentISS:ARUK-UCL
Biological Process regulation of cell adhesionIEA:Ensembl
Cellular Location
Secreted
Cytoplasmic vesicle, secretory vesicle lumen
Involvement in disease
Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB):
A neurodegenerative disease clinically characterized by dementia. Additional features include intellectual decline, psychic seizures, progressive myoclonic epilepsy, and cerebral atrophy. Histologically, it is characterized by the presence of eosinophilic inclusion bodies (called Collins bodies) throughout the deeper layers of the cerebral cortex, leading to neuronal death.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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