SERPINI1

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
Full Name
serpin peptidase inhibitor, clade I (neuroserpin), member 1
Function
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376).
May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
Biological Process
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peripheral nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of neuron projection developmentISS:ARUK-UCL
Biological Process regulation of cell adhesionIEA:Ensembl
Cellular Location
Secreted
Cytoplasmic vesicle, secretory vesicle lumen
Involvement in disease
Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB):
A neurodegenerative disease clinically characterized by dementia. Additional features include intellectual decline, psychic seizures, progressive myoclonic epilepsy, and cerebral atrophy. Histologically, it is characterized by the presence of eosinophilic inclusion bodies (called Collins bodies) throughout the deeper layers of the cerebral cortex, leading to neuronal death.
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Anti-SERPINI1 antibodies

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Mouse Anti-SERPINI1 Recombinant Antibody (1E10) (CBMAB-A8008-LY)

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Target: SERPINI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E10
Application*: WB, E
Datasheet SDS

Rat Anti-SERPINI1 Recombinant Antibody (CBXS-3464) (CBMAB-S6195-CQ)

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Target: SERPINI1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXS-3464
Application*: E, WB
Datasheet SDS

Mouse Anti-SERPINI1 Recombinant Antibody (CBXS-2752) (CBMAB-S5503-CQ)

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Target: SERPINI1
Host: Mouse
Specificity: Human
Clone: CBXS-2752
Application*: E, WB
Datasheet SDS

Rat Anti-SERPINI1 Recombinant Antibody (CBXS-1827) (CBMAB-S4633-CQ)

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Target: SERPINI1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXS-1827
Application*: WB
Datasheet SDS

Rabbit Anti-SERPINI1 Recombinant Antibody (CBXS-1157) (CBMAB-S4039-CQ)

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Target: SERPINI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1157
Application*: E, WB
Datasheet SDS

Mouse Anti-SERPINI1 Recombinant Antibody (CBXS-0270) (CBMAB-S3246-CQ)

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Target: SERPINI1
Host: Mouse
Specificity: Human
Clone: CBXS-0270
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SERPINI1 Recombinant Antibody (CBXS-3956) (CBMAB-S1219-CQ)

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Target: SERPINI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3956
Application*: WB, P
Datasheet SDS

Rabbit Anti-SERPINI1 Recombinant Antibody (CBXS-5942) (CBMAB-S0791-CQ)

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Target: SERPINI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-5942
Application*: E
Datasheet SDS

Mouse Anti-SERPINI1 Recombinant Antibody (9A7) (CBMAB-N4258-WJ)

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Target: SERPINI1
Host: Mouse
Specificity: Human
Clone: 9A7
Application*: WB
Datasheet SDS

Mouse Anti-SERPINI1 Recombinant Antibody (1D10) (CBMAB-N4257-WJ)

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Target: SERPINI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D10
Application*: E, P, WB
Datasheet SDS

Mouse Anti-SERPINI1 Recombinant Antibody (CBWJN-1672) (CBMAB-N4255-WJ)

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Target: SERPINI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1672
Application*: E, P
Datasheet SDS

Rabbit Anti-SERPINI1 Recombinant Antibody (CBWJN-1671) (CBMAB-N4254-WJ)

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Target: SERPINI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJN-1671
Application*: P
Datasheet SDS

Rabbit Anti-SERPINI1 Recombinant Antibody (CBWJN-1670) (CBMAB-N4253-WJ)

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Target: SERPINI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1670
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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