Mouse Anti-SETD6 Recombinant Antibody (CBXS-0282) (CBMAB-S3257-CQ)

Name: Mouse Anti-SETD6 Recombinant Antibody (CBXS-0282)
SKU: CBMAB-S3257-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-0282

Application

IHC-P, WB

Immunogen

Recombinant protein encompassing a sequence within the center region of human SETD6

Specificity

Human

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SETD6

Introduction

This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

79918

UniProt ID

Q8TBK2

Alternative Names

SET Domain Containing 6; SET Domain-Containing Protein 6; EC 2.1.1.-;

Function

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity (PubMed:21131967, PubMed:30189201, PubMed:21515635).
Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626).
Required for the maintenance of embryonic stem cell self-renewal (By similarity).
Methylates PAK4.

Biological Process

Biological Process histone lysine methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process stem cell differentiationISS:UniProtKB
Biological Process stem cell population maintenanceISS:UniProtKB

Cellular Location

Nucleus

PTM

Automethylated; Lys-39 and Lys-179 serve as the major automethylation sites.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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