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Mouse Anti-SETD6 Recombinant Antibody (CBXS-5786) (CBMAB-S0644-CQ)

This product is a mouse antibody that recognizes SETD6. The antibody CBXS-5786 can be used for immunoassay techniques such as: WB, IHC, IHC-P.
See all SETD6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5786
Antibody Isotype
IgG2b
Application
WB, IHC, IHC-P

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the center region of human SETD6
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SETD6
Introduction
This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
79918
UniProt ID
Q8TBK2
Alternative Names
SET Domain Containing 6; SET Domain-Containing Protein 6; EC 2.1.1.-;
Function
Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity (PubMed:21131967, PubMed:30189201, PubMed:21515635).
Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626).
Required for the maintenance of embryonic stem cell self-renewal (By similarity).
Methylates PAK4.
Biological Process
Biological Process histone lysine methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process stem cell differentiationISS:UniProtKB
Biological Process stem cell population maintenanceISS:UniProtKB
Cellular Location
Nucleus
PTM
Automethylated; Lys-39 and Lys-179 serve as the major automethylation sites.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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