SETD6

This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants.

Full Name

SETD6

Function

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity (PubMed:21131967, PubMed:30189201, PubMed:21515635).
Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626).
Required for the maintenance of embryonic stem cell self-renewal (By similarity).
Methylates PAK4.

Biological Process

Biological Process histone lysine methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process stem cell differentiationISS:UniProtKB
Biological Process stem cell population maintenanceISS:UniProtKB

Cellular Location

Nucleus

PTM

Automethylated; Lys-39 and Lys-179 serve as the major automethylation sites.