Human Recombinant SETD6, Active protein, GST Tag (V2LY-0526-LY6734)

Name: Human Recombinant SETD6, Active protein, GST Tag
SKU: V2LY-0526-LY6734
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant SETD6, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 75 kDa.

Molecule Mass

75 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

SETD6

Function

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity (PubMed:21131967, PubMed:30189201, PubMed:21515635).
Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626).
Required for the maintenance of embryonic stem cell self-renewal (By similarity).
Methylates PAK4.

Biological Process

Biological Process histone lysine methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process stem cell differentiationISS:UniProtKB
Biological Process stem cell population maintenanceISS:UniProtKB

Cellular Location

Nucleus

PTM

Automethylated; Lys-39 and Lys-179 serve as the major automethylation sites.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Mouse Anti-SETD6 Recombinant Antibody (CBXS-5786) (CAT#: CBMAB-S0644-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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