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Mouse Anti-SS18 Recombinant Antibody (1C8) (CBMAB-A8601-LY)

The product is antibody recognizes SS18. The antibody 1C8 immunoassay techniques such as: WB, ELISA.
See all SS18 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SS18 (NP_001007560.1, 116 a.a. ~ 216 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SS18, NBAF Chromatin Remodeling Complex Subunit
Entrez Gene ID
6760
UniProt ID
Q15532
Alternative Names
MGC116875; SSXT; SYT; SYT-SSX1; SYT-SSX2
Function
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
Biological Process
Biological Process cell morphogenesisIEA:Ensembl
Biological Process chromatin remodeling1 PublicationIC:ComplexPortal
Biological Process ephrin receptor signaling pathwayIEA:Ensembl
Biological Process intracellular signal transductionIEA:Ensembl
Biological Process microtubule cytoskeleton organizationIEA:Ensembl
Biological Process negative regulation of cell differentiation1 PublicationIC:ComplexPortal
Biological Process neuronal stem cell population maintenanceIEA:Ensembl
Biological Process positive regulation of cell population proliferation1 PublicationIC:ComplexPortal
Biological Process positive regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of transcription by RNA polymerase II1 PublicationIC:ComplexPortal
Biological Process response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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