Mouse Anti-SS18 Recombinant Antibody (CBXS-5058) (CBMAB-S2279-CQ)

Name: Mouse Anti-SS18 Recombinant Antibody (CBXS-5058)
SKU: CBMAB-S2279-CQ
Rating: 5 (1 reviews)

See all SS18 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-5058

Application

Immunogen

Human recombinant protein fragment corresponding to amino acids 227-255 of human SS18(NP_001007560)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SS18, NBAF Chromatin Remodeling Complex Subunit

Introduction

SS18 (SS18, NBAF Chromatin Remodeling Complex Subunit) is a Protein Coding gene. Diseases associated with SS18 include Sarcoma, Synovial and Sarcoma. Among its related pathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is SS18L1.

Entrez Gene ID

6760

UniProt ID

Q15532

Alternative Names

SS18, NBAF Chromatin Remodeling Complex Subunit; Synovial Sarcoma Translocated To X Chromosome Protein; Synovial Sarcoma Translocation, Chromosome 18; SSXT; SYT; Synovial Sarcoma, Translocated To X Chromosome; Protein SSXT; Protein SYT;

Function

Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).

Biological Process

Biological Process cell morphogenesisIEA:Ensembl
Biological Process chromatin remodeling1 PublicationIC:ComplexPortal
Biological Process ephrin receptor signaling pathwayIEA:Ensembl
Biological Process intracellular signal transductionIEA:Ensembl
Biological Process microtubule cytoskeleton organizationIEA:Ensembl
Biological Process negative regulation of cell differentiation1 PublicationIC:ComplexPortal
Biological Process neuronal stem cell population maintenanceIEA:Ensembl
Biological Process positive regulation of cell population proliferation1 PublicationIC:ComplexPortal
Biological Process positive regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of transcription by RNA polymerase II1 PublicationIC:ComplexPortal
Biological Process response to xenobiotic stimulusIEA:Ensembl

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-SS18 Recombinant Antibody (CBXS-5058)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SS18 Recombinant Antibody (CBXS-3944) (CAT#: CBMAB-S1207-CQ)

Rabbit Anti-SS18 Recombinant Antibody (D6I4Z) (CAT#: CBMAB-CP2580-LY)

Mouse Anti-SS18 Recombinant Antibody (CBXS-2003) (CAT#: CBMAB-S4770-CQ)

Mouse Anti-SS18 Recombinant Antibody (1C8) (CAT#: CBMAB-A8601-LY)

Rabbit Anti-SS18 Recombinant Antibody (CBXS-5421) (CAT#: CBMAB-S2632-CQ)

Mouse Anti-SS18 Recombinant Antibody (CBXS-2096) (CAT#: CBMAB-S4861-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry