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Rabbit Anti-SS18 Recombinant Antibody (D6I4Z) (CBMAB-CP2580-LY)

The product is antibody recognizes SS18. The antibody D6I4Z immunoassay techniques such as: WB,IP,IHC-P,CIP,CIP-seq.
See all SS18 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Dog, Horse
Clone
D6I4Z
Antibody Isotype
IgG
Application
WB, IP, IHC-P, CIP, CIP-seq

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln394 of human SS18 protein.
Specificity
Human, Mouse, Rat, Monkey, Dog, Horse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SS18, NBAF Chromatin Remodeling Complex Subunit
Introduction
SS18 (SS18, NBAF Chromatin Remodeling Complex Subunit) is a Protein Coding gene. Diseases associated with SS18 include Sarcoma, Synovial and Sarcoma. Among its related pathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is SS18L1.
Entrez Gene ID
Human6760
Mouse268996
Rat361295
Monkey709897
Dog480171
Horse100051844
UniProt ID
HumanQ15532
MouseQ62280
RatB0BN04
MonkeyF7EQE4
DogA0A8C0SQ47
HorseF7E3T8
Alternative Names
SS18; NBAF Chromatin Remodeling Complex Subunit; Synovial Sarcoma Translocated To X Chromosome Protein; Synovial Sarcoma Translocation; Chromosome 18; SSXT; SYT; Synovial Sarcoma; Translocated To X Chromosome; Protein SSXT; Protein SYT;
Function
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
Biological Process
Biological Process cell morphogenesisIEA:Ensembl
Biological Process chromatin remodeling1 PublicationIC:ComplexPortal
Biological Process ephrin receptor signaling pathwayIEA:Ensembl
Biological Process intracellular signal transductionIEA:Ensembl
Biological Process microtubule cytoskeleton organizationIEA:Ensembl
Biological Process negative regulation of cell differentiation1 PublicationIC:ComplexPortal
Biological Process neuronal stem cell population maintenanceIEA:Ensembl
Biological Process positive regulation of cell population proliferation1 PublicationIC:ComplexPortal
Biological Process positive regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of transcription by RNA polymerase II1 PublicationIC:ComplexPortal
Biological Process response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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