Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263)

Name: Mouse Anti-SSH1 Recombinant Antibody (CBT4676)
SKU: V2LY-0625-LY263
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263) in FC

Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263) in IHC

Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263) in ELISA

Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4676

Application

IHC, FC

Immunogen

Synthesized peptide fragment of human SLINGSHOT-1L (AA: 1032-1044 ) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC-P	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Slingshot Protein Phosphatase 1

Entrez Gene ID

54434

Function

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Biological Process

Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to ATPManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of actin filament polymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cellular protein metabolic processManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Cleavage furrow
Midbody
Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.

PTM

Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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