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Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263)


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Tested Data
Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263) in FC
Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263) in FC
Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263) in IHC
Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263) in IHC
Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263) in ELISA
Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263) in ELISA

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4676
Antibody Isotype
IgG1
Application
IHC, FC

Basic Information

Immunogen
Synthesized peptide fragment of human SLINGSHOT-1L (AA: 1032-1044 ) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
54434
Function
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to ATPManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of actin filament polymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cellular protein metabolic processManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Cleavage furrow
Midbody
Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.
PTM
Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.
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For research use only. Not intended for any clinical use.

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