Sign in or Register   Sign in or Register
  |  

Mouse Anti-SSH1 Recombinant Antibody (CBXS-3974) (CBMAB-S1237-CQ)

This product is a mouse antibody that recognizes SSH1. The antibody CBXS-3974 can be used for immunoassay techniques such as: ELISA, WB.
See all SSH1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3974
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Slingshot Protein Phosphatase 1
Introduction
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Entrez Gene ID
54434
UniProt ID
Q8WYL5
Alternative Names
Slingshot Protein Phosphatase 1; SSH-Like Protein 1; HSSH-1L; SSH1L; Protein Phosphatase Slingshot Homolog 1; Slingshot Homolog 1 (Drosophila);
Function
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to ATPManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of actin filament polymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cellular protein metabolic processManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Cleavage furrow
Midbody
Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.
PTM
Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SSH1 Recombinant Antibody (CBXS-3974)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare