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SSH1

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Full Name

Slingshot Protein Phosphatase 1

Function

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Biological Process

Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to ATPManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of actin filament polymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cellular protein metabolic processManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Cleavage furrow
Midbody
Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.

PTM

Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.

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Anti-SSH1 antibodies

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Rabbit Anti-SSH1 Recombinant Antibody (E1K3W) (CBMAB-CP2582-LY)

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Target: SSH1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: E1K3W

Application*: WB, IP

Mouse Anti-SSH1 Recombinant Antibody (2F9) (CBMAB-A8608-LY)

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Target: SSH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2F9

Application*: WB, E

Mouse Anti-SSH1 Recombinant Antibody (CBXS-2929) (CBMAB-S5678-CQ)

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Target: SSH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-2929

Application*: E, WB

Mouse Anti-SSH1 Recombinant Antibody (CBXS-0731) (CBMAB-S3662-CQ)

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Target: SSH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-0731

Application*: SE, E, WB

Mouse Anti-SSH1 Recombinant Antibody (CBXS-4750) (CBMAB-S1979-CQ)

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Target: SSH1

Host: Mouse

Specificity: Human

Clone: CBXS-4750

Application*: IF, F

Mouse Anti-SSH1 Recombinant Antibody (CBXS-3974) (CBMAB-S1237-CQ)

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Target: SSH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3974

Application*: E, WB

Rabbit Anti-SSH1 Recombinant Antibody (CBXS-6011) (CBMAB-S0857-CQ)

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Target: SSH1

Host: Rabbit

Specificity: Human, Mouse, Rat

Clone: CBXS-6011

Application*: WB, IP

Mouse Anti-SSH1 Recombinant Antibody (6C11G9) (CBMAB-S0278-CQ)

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Target: SSH1

Host: Mouse

Specificity: Human

Clone: 6C11G9

Application*: WB, F, E, IH, P, IC, MC

Mouse Anti-SSH1 Recombinant Antibody (CBXS-3821) (CBMAB-S0223-CQ)

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Target: SSH1

Host: Mouse

Specificity: Human

Clone: CBXS-3821

Application*: WB, F, E, IH, IF, IC, MC

Mouse Anti-SSH1 Recombinant Antibody (CBT4676) (V2LY-0625-LY263)

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Target: SSH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT4676

Application*: IH, F

Mouse Anti-SSH1 Recombinant Antibody (CBT2871) (V2LY-0625-LY262)

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Target: SSH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2871

Application*: IC, F

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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