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Mouse Anti-SSR1 Recombinant Antibody (CBYJT-1687) (CBMAB-T0737-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to SSR1 (Signal Sequence Receptor Subunit 1). The antibody can be used for immunoassay techniques, such as WB, IHC-P.
See all SSR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1687
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
signal sequence receptor, alpha
Introduction
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by SSR1 and a 22-kD glycoprotein. SSR1 generates several mRNA species as a result of complex alternative polyadenylation. SSR1 is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical.
Entrez Gene ID
6745
UniProt ID
P43307
Alternative Names
Signal Sequence Receptor Subunit 1; Signal Sequence Receptor Subunit Alpha; Signal Sequence Receptor, Alpha; SSR-Alpha; TRAPA; Translocon-Associated Protein Alpha Subunit
Function
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
Biological Process
Biological Process cotranslational protein targeting to membraneManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Endoplasmic reticulum membrane
Topology
Lumenal: 19-207
Helical: 208-228
Cytoplasmic: 229-286
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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