Mouse Anti-TCL1A Recombinant Antibody (1C4) (CBMAB-A8973-LY)

Name: Mouse Anti-TCL1A Recombinant Antibody (1C4)
SKU: CBMAB-A8973-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1C4

Application

sELISA, ELISA

Immunogen

TCL1A (NP_068801.1, 61 a.a. ~ 114 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TCL1A Gene(Protein Coding) T Cell Leukemia/Lymphoma 1A

Entrez Gene ID

8115

UniProt ID

P56279

Alternative Names

TCL1

Function

Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.

Biological Process

Biological Process cellular response to tumor necrosis factorIDA:UniProtKB1 Publication
Biological Process negative regulation of apoptotic processIDA:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationIDA:UniProtKB1 Publication
Biological Process positive regulation of mitochondrial membrane potentialIDA:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-serine phosphorylationIMP:UniProtKB1 Publication
Biological Process positive regulation of protein serine/threonine kinase activityIDA:UniProtKB1 Publication
Biological Process positive regulation of protein-containing complex assemblyIDA:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus
Microsome
Endoplasmic reticulum
Microsomal fraction.

Involvement in disease

Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TCL1A Matched Antibody Pair (1192) (CAT#: APMAB-1192LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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