ELISA, WB, IHC-P, IF, ICC, FC
Human TCL1A expressed in E. coli
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
TCL1A is a subunit of TCL1. Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 plays a role as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).
T Cell Leukemia/Lymphoma 1A; T-Cell Leukemia/Lymphoma 1A; Protein P14 TCL1; Oncogene TCL-1; Oncogene TCL1; TCL1; T-Cell Leukemia/Lymphoma Protein 1A; T-Cell Lymphoma-1