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TCL1A

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Full Name
TCL1A Gene(Protein Coding) T Cell Leukemia/Lymphoma 1A
Function
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
Biological Process
Biological Process cellular response to tumor necrosis factorIDA:UniProtKB1 Publication
Biological Process negative regulation of apoptotic processIDA:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationIDA:UniProtKB1 Publication
Biological Process positive regulation of mitochondrial membrane potentialIDA:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-serine phosphorylationIMP:UniProtKB1 Publication
Biological Process positive regulation of protein serine/threonine kinase activityIDA:UniProtKB1 Publication
Biological Process positive regulation of protein-containing complex assemblyIDA:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Microsome
Endoplasmic reticulum
Microsomal fraction.
Involvement in disease
Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.

Anti-TCL1A antibodies

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Mouse Anti-TCL1A Recombinant Antibody (CBYJT-2313) (CBMAB-T1423-YJ)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2313
Application*: P, C

Mouse Anti-TCL1A Recombinant Antibody (CBYJT-2312) (CBMAB-T1422-YJ)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2312
Application*: F, P, IP, WB

Mouse Anti-TCL1A Recombinant Antibody (CBYJT-2311) (CBMAB-T1421-YJ)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-2311
Application*: WB, IP, P, F

Mouse Anti-TCL1A Recombinant Antibody (CBYJT-2310) (CBMAB-T1420-YJ)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2310
Application*: WB, F, IH, IP, P

Mouse Anti-TCL1A Recombinant Antibody (CBYJT-2309) (CBMAB-T1419-YJ)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2309
Application*: E, IP

Mouse Anti-TCL1A Recombinant Antibody (CBYJT-2308) (CBMAB-T1418-YJ)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2308
Application*: E, WB, P, IF, IC, F

Mouse Anti-TCL1A Recombinant Antibody (CBYJT-2307) (CBMAB-T1417-YJ)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2307
Application*: IS

Mouse Anti-TCL1A Recombinant Antibody (CBYJT-2306) (CBMAB-T1416-YJ)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-2306
Application*: E, F, IC, IF, IH, IP, WB

Mouse Anti-TCL1A Recombinant Antibody (1-21) (CBMAB-CP2725-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: 1-21
Application*: WB, IP

Mouse Anti-TCL1A Recombinant Antibody (3H6) (CBMAB-A8981-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H6
Application*: SE, E

Mouse Anti-TCL1A Recombinant Antibody (3G5) (CBMAB-A8980-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G5
Application*: SE, E

Mouse Anti-TCL1A Recombinant Antibody (3G10) (CBMAB-A8979-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G10
Application*: SE, E

Mouse Anti-TCL1A Recombinant Antibody (3A4) (CBMAB-A8978-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3A4
Application*: SE, E

Mouse Anti-TCL1A Recombinant Antibody (2F7) (CBMAB-A8977-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F7
Application*: SE, E

Mouse Anti-TCL1A Recombinant Antibody (2F1) (CBMAB-A8976-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F1
Application*: WB, E

Mouse Anti-TCL1A Recombinant Antibody (2D7) (CBMAB-A8975-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2D7
Application*: WB, E

Mouse Anti-TCL1A Recombinant Antibody (1G10) (CBMAB-A8974-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G10
Application*: IF, E

Mouse Anti-TCL1A Recombinant Antibody (1C4) (CBMAB-A8973-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C4
Application*: SE, E

Mouse Anti-TCL1A Recombinant Antibody (1E8) (CBMAB-A8972-LY)

Datasheet SDS
Target: TCL1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E8
Application*: SE, E

TCL1A Matched Antibody Pair (1192) (APMAB-1192LY)

Datasheet SDS
Target: TCL1A
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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