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Mouse Anti-TCL1A Recombinant Antibody (3H6) (CBMAB-A8981-LY)

The product is antibody recognizes TCL1A. The antibody 3H6 immunoassay techniques such as: sELISA, ELISA.
See all TCL1A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H6
Antibody Isotype
IgG1, κ
Application
sELISA, ELISA

Basic Information

Immunogen
TCL1A (NP_068801.1, 61 a.a. ~ 114 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TCL1A Gene(Protein Coding) T Cell Leukemia/Lymphoma 1A
Entrez Gene ID
8115
UniProt ID
P56279
Alternative Names
TCL1
Function
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
Biological Process
Biological Process cellular response to tumor necrosis factorIDA:UniProtKB1 Publication
Biological Process negative regulation of apoptotic processIDA:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationIDA:UniProtKB1 Publication
Biological Process positive regulation of mitochondrial membrane potentialIDA:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-serine phosphorylationIMP:UniProtKB1 Publication
Biological Process positive regulation of protein serine/threonine kinase activityIDA:UniProtKB1 Publication
Biological Process positive regulation of protein-containing complex assemblyIDA:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Microsome
Endoplasmic reticulum
Microsomal fraction.
Involvement in disease
Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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