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Mouse Anti-TCL1A Recombinant Antibody (CBYJT-2311) (CBMAB-T1421-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TCL1A (T Cell Leukemia/Lymphoma 1A). The antibody can be used for immunoassay techniques, such as WB, IP, IHC-P, FC.
See all TCL1A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2311
Antibody Isotype
IgG2b
Application
WB, IP, IHC-P, FC

Basic Information

Immunogen
Synthetic peptide (Human)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-21

Target

Full Name
TCL1A Gene(Protein Coding) T Cell Leukemia/Lymphoma 1A
Introduction
TCL1A is a subunit of TCL1. Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 plays a role as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).
Entrez Gene ID
UniProt ID
Alternative Names
BZP; TCF8; AREB6; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1
Function
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
Biological Process
Biological Process cellular response to tumor necrosis factorIDA:UniProtKB1 Publication
Biological Process negative regulation of apoptotic processIDA:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationIDA:UniProtKB1 Publication
Biological Process positive regulation of mitochondrial membrane potentialIDA:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-serine phosphorylationIMP:UniProtKB1 Publication
Biological Process positive regulation of protein serine/threonine kinase activityIDA:UniProtKB1 Publication
Biological Process positive regulation of protein-containing complex assemblyIDA:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Microsome
Endoplasmic reticulum
Microsomal fraction.
Involvement in disease
Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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