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Mouse Anti-TDO2 Recombinant Antibody (1C8) (CBMAB-A8988-LY)

The product is antibody recognizes TDO2. The antibody 1C8 immunoassay techniques such as: sELISA, ELISA.
See all TDO2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C8
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
TDO2 (NP_005642, 307 a.a. ~ 405 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
tryptophan 2,3-dioxygenase
Introduction
Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.[supplied by OMIM
Entrez Gene ID
6999
UniProt ID
P48775
Alternative Names
TDO; TPH2; TRPO
Function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Biological Process
Biological Process protein homotetramerizationIDA:UniProtKB2 Publications
Biological Process response to nitroglycerinIEA:Ensembl
Biological Process tryptophan catabolic process to acetyl-CoAIBA:GO_Central1 Publication
Biological Process tryptophan catabolic process to kynurenineIDA:UniProtKB1 Publication
Cellular Location
Cytosol
Involvement in disease
Hypertryptophanemia (HYPTRP):
An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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