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TDO2

Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.[supplied by OMIM

Full Name

tryptophan 2,3-dioxygenase

Function

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Biological Process

Biological Process protein homotetramerizationIDA:UniProtKB2 Publications
Biological Process response to nitroglycerinIEA:Ensembl
Biological Process tryptophan catabolic process to acetyl-CoAIBA:GO_Central1 Publication
Biological Process tryptophan catabolic process to kynurenineIDA:UniProtKB1 Publication

Cellular Location

Cytosol

Involvement in disease

Hypertryptophanemia (HYPTRP):
An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia.

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Anti-TDO2 antibodies

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Mouse Anti-TDO2 Recombinant Antibody (1C8) (CBMAB-A8988-LY)

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Target: TDO2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1C8

Application*: SE, E

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2446) (CBMAB-T1592-YJ)

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Target: TDO2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBYJT-2446

Application*: IH, WB

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2445) (CBMAB-T1591-YJ)

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Target: TDO2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-2445

Application*: P, WB

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2443) (CBMAB-T1589-YJ)

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Target: TDO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2443

Application*: WB, IH

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2442) (CBMAB-T1588-YJ)

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Target: TDO2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-2442

Application*: E

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2441) (CBMAB-T1587-YJ)

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Target: TDO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2441

Application*: WB

Human Recombinant TDO2 protein, GST Tag (V2LY-0526-LY7149)

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Target: TDO2

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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