TDO2

Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.[supplied by OMIM

Full Name

tryptophan 2,3-dioxygenase

Function

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Biological Process

Biological Process protein homotetramerizationIDA:UniProtKB2 Publications
Biological Process response to nitroglycerinIEA:Ensembl
Biological Process tryptophan catabolic process to acetyl-CoAIBA:GO_Central1 Publication
Biological Process tryptophan catabolic process to kynurenineIDA:UniProtKB1 Publication

Cellular Location

Cytosol

Involvement in disease

Hypertryptophanemia (HYPTRP):
An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia.

Anti-TDO2 antibodies

Mouse Anti-TDO2 Recombinant Antibody (1C8) (CBMAB-A8988-LY)

Datasheet

SDS

Target: TDO2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1C8

Application*: SE, E

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2441) (CBMAB-T1587-YJ)

Datasheet

SDS

Target: TDO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2441

Application*: WB

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2442) (CBMAB-T1588-YJ)

Datasheet

SDS

Target: TDO2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-2442

Application*: E

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2443) (CBMAB-T1589-YJ)

Datasheet

SDS

Target: TDO2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2443

Application*: WB, IH

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2445) (CBMAB-T1591-YJ)

Datasheet

SDS

Target: TDO2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-2445

Application*: P, WB

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2446) (CBMAB-T1592-YJ)

Datasheet

SDS

Target: TDO2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBYJT-2446

Application*: IH, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)