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TDO2

Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.[supplied by OMIM
Full Name
tryptophan 2,3-dioxygenase
Function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Biological Process
Biological Process protein homotetramerizationIDA:UniProtKB2 Publications
Biological Process response to nitroglycerinIEA:Ensembl
Biological Process tryptophan catabolic process to acetyl-CoAIBA:GO_Central1 Publication
Biological Process tryptophan catabolic process to kynurenineIDA:UniProtKB1 Publication
Cellular Location
Cytosol
Involvement in disease
Hypertryptophanemia (HYPTRP):
An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia.
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Anti-TDO2 antibodies

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Mouse Anti-TDO2 Recombinant Antibody (1C8) (CBMAB-A8988-LY)

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Target: TDO2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C8
Application*: SE, E
Datasheet SDS

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2446) (CBMAB-T1592-YJ)

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Target: TDO2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYJT-2446
Application*: IH, WB
Datasheet SDS

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2445) (CBMAB-T1591-YJ)

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Target: TDO2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-2445
Application*: P, WB
Datasheet SDS

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2443) (CBMAB-T1589-YJ)

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Target: TDO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2443
Application*: WB, IH
Datasheet SDS

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2442) (CBMAB-T1588-YJ)

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Target: TDO2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2442
Application*: E
Datasheet SDS

Mouse Anti-TDO2 Recombinant Antibody (CBYJT-2441) (CBMAB-T1587-YJ)

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Target: TDO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2441
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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